Familial occurrence of cavernous angiomata of the brain.
نویسنده
چکیده
A 27 year old man had attacks of violence for three years before he died in 1945. Necropsy revealed multiple cavernous angiomata of the brain. This man's daughter died in 1969 at the age of 28 years after a year of intermittent headaches. Necropsy showed a large cavernous angioma in the right temporal lobe. Until now the literature has contained only scanty circumstantial evidence for a familial occurrence of cavernous angiomata of the brain.
منابع مشابه
Clinical progression and familial occurrence of cerebral cavernous angiomas: the role of angiogenic and growth factors.
OBJECT The authors studied the expression of angiogenic and growth factors and various proliferative indices in cavernous angiomas of the brain. The goal was to define whether the often progressive clinical course of both sporadic and familial forms of the lesion is correlated with different expression of these factors. METHODS Forty-three cavernomas of the brain were investigated with immuno...
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A 16-year-old girl presented with multiple cerebral cavernous angiomas with calcifications due to repeated hemorrhages and a thrombosed cerebral arteriovenous malformation (AVM). Her 18-year-old elder sister also had multiple cerebral cavernous angiomas associated with calcifications, which suggested presence of repeated previous hemorrhages. Surgical removal via a right occipital craniotomy re...
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BACKGROUND Cerebral cavernous malformations (CCMs) are congenital vascular anomalies that can cause seizures, intracranial hemorrhages, focal neurological deficits, and migrainelike headaches. Magnetic resonance (MR) imaging has substantially facilitated diagnosis of CCM. It is now widely accepted that familial clustering with an autosomal dominant inheritance pattern should be suspected in cas...
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BACKGROUND AND PURPOSE Familial cerebral cavernous malformations, an autosomal dominant disorder, result in excess morbidity and mortality in affected patients. The disorder is most prevalent in the Southwest United States, where the affected families are most often carriers of the CCM1-KRIT1 Common Hispanic Mutation. The brain and spinal cord parenchyma in these individuals is usually affected...
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ورودعنوان ژورنال:
- Journal of neurology, neurosurgery, and psychiatry
دوره 33 6 شماره
صفحات -
تاریخ انتشار 1970